Vitamin B2 / Riboflavin

Riboflavin (vitamin B2) is one of the most well-studied vitamins for migraine prevention, with multiple clinical trials showing benefit at higher doses, commonly around 400 mg per day. Like CoQ10, riboflavin supports mitochondrial energy production in the brain, which is believed to play a role in migraine disease.

I like Nutricost for riboflavin because the dosing aligns with what’s used in research, the ingredient list is simple, and the brand consistently offers quality supplements without unnecessary fillers.